Alignment of alleles: Atlantic cod (Gadus morhua) IGHV3S11

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20 
                                 C   E   Q   L   T   Q   P   G   S       L   T   I   Q   P   G   Q   P   L   T 
  AJ274737,IGHV3S11*01, 12-03b  TGT GAA CAG CTT ACT CAG CCA GGG TCT ... CTG ACT ATC CAA CCT GGT CAA CCT CTG ACC
                                                                                                               
  AJ279375,IGHV3S11*02, 127     --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- ---
                                                                                                               
  AJ274756,IGHV3S11*03, 20-05  

                                                        ___________________CDR1-IMGT____________________        
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40 
                                 I   R   C   Q   V   S   Y   T   L   N   Y   W                           T   H 
  AJ274737,IGHV3S11*01, 12-03b  ATC CGC TGC CAG GTC TCC TAT ACA CTT AAC TAC TGG ... ... ... ... ... ... ACA CAT
                                                                                                               
  AJ279375,IGHV3S11*02, 127     --- --- --T --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... --- ---
                                             G   R                                                             
  AJ274756,IGHV3S11*03, 20-05        T- --- GGC CG- --- --- --- --- --- --- --- ... ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   E   G   N   S   L   E   W   I   G   F   I   Y   T   G   D 
  AJ274737,IGHV3S11*01, 12-03b  TGG ATC AGA CAA CCT GAA GGA AAC TCA CTG GAA TGG ATT GGA TTC ATT TAT ACC GGG GAC
                                                                                                               
  AJ279375,IGHV3S11*02, 127     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                                                 S           N 
  AJ274756,IGHV3S11*03, 20-05   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- -C- --- --- A--

                                IMGT________________                                                            
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80 
                                 K                   K   V   K   D   S   L   S       S   K   F   S   L   S   L 
  AJ274737,IGHV3S11*01, 12-03b  AAA ... ... ... ... AAA GTG AAA GAC TCC CTT AGT ... AGT AAA TTC AGT CTT TCC CTT
                                                                                                               
  AJ279375,IGHV3S11*02, 127     --- ... ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---
                                                                                                               
  AJ274756,IGHV3S11*03, 20-05   --- ... ... ... ... --- --- --- --- --- --- --C ... --- --- --- --- --- --- ---

                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100 
                                 D   E   A   S   K   T   V   T   L   Q   G   Q   N   M   Q   P   G   D   S   A 
  AJ274737,IGHV3S11*01, 12-03b  GAC GAG GCC AGT AAA ACA GTC ACT TTG CAA GGG CAA AAC ATG CAG CCT GGA GAC TCA GCT
                                                                                                               
  AJ279375,IGHV3S11*02, 127     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
                                                                         E                                     
  AJ274756,IGHV3S11*03, 20-05   --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- --- --- --- --- ---

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 V   Y   Y   C   A   G 
  AJ274737,IGHV3S11*01, 12-03b  GTG TAT TAC TGT GCC GGA     #c
                                                     R 
  AJ279375,IGHV3S11*02, 127     --- --- --- --- --- A-G     #c
                                                     R 
  AJ274756,IGHV3S11*03, 20-05   --- --- --- --- --- A-G     #c


#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc